Special Episode: Philip Eil & Prescription for Pain

For decades, it seemed like the appendix would go the way of 8-track players, pagers, and the phonograph. Outdated, obsolete, not worth keeping around. Surgeons performed appendectomies like it was spring cleaning - when in doubt, cut it out. But then the tides began to turn as medicine started to question the long-held belief that the appendix is a defunct organ (on a good day) or a ticking time bomb (on a very bad one). In this episode, we trace the story of the appendix from its earliest descriptions to the latest advancements in treatment of appendicitis. If you’ve ever wondered whether the appendix actually serves any function and what that function might be, then this is the episode for you! Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu Learn more about your ad choices. Visit megaphone.fm/adchoices

Among the many conditions that creep under your skin and make scratching irresistible, scabies alone holds the honor of being called simply “The Itch” for centuries. In this episode, we examine how the burrowing scabies mites cause this extremely uncomfortable sensation, what we can do to halt their progress, and how contagious they really are (less than you probably think). Today, the word scabies instantly conjures up images of the mite responsible for The Itch, but for centuries, medicine failed to make that connection, even when the proof was right in front of them and when traditional wisdom had long since known mite=scabies. Tune in to learn how the great scabies debate was finally resolved with a public demonstration, what role conscientious objectors played in scabies research during WWII, and where we are with scabies around the globe today. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu Learn more about your ad choices. Visit megaphone.fm/adchoices

A mere 150 years ago, uttering the words “scarlet fever” was enough to strike fear into the hearts of many, especially parents of young children. For a brief period of time, this disease, caused by an infection with the bacterium Streptococcus pyogenes, reigned as a leading cause of childhood death in many parts of the world. It left its mark on gravestones, in public health decrees, in literature like the Velveteen Rabbit, but then something changed. The disease became milder, no longer the deadly threat it once was. But it didn’t go away entirely or lose its bite completely. In this episode, we examine the biology of scarlet fever and trace how it can make you sick before exploring its strange and tragic history. How did such a deadly disease change almost overnight, before any effective treatment was developed? And what can that tell us about its potential to change back? Tune in to find out. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu Learn more about your ad choices. Visit megaphone.fm/adchoices

We really don’t give fungi the credit they deserve. Over the years of this podcast, we’ve covered only a handful of fungal pathogens, and pathogenic fungi themselves represent a teeny tiny proportion of the incredible diversity of fungal life on this planet. But with this book club episode, we’re attempting to correct this oversight, at least a little bit. Toxicologist and science writer Dr. Emily Monosson joins us to discuss her book Blight: Fungi and the Coming Pandemic. We chat about how fungal epidemics have shaped entire ecosystems, altered economies, and invaded hospitals. Despite the devastating impact pathogenic fungi have made, we still underappreciate their potential to cause harm in the future, as our climate changes, as our land use changes, and as globalization continues. In Blight, Monosson delivers an important reminder that we should use what we have learned about these historical outbreaks to limit the harm fungi may cause in the future. Tune in today to gain a new appreciation for this incredible group of organisms. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu Learn more about your ad choices. Visit megaphone.fm/adchoices

That same little bottle of retinol serum sitting on your bathroom counter - how does it work? Does it actually work? Those are the questions we’re taking on in part two of our retinoids two-parter. The answers, as you might expect, are complicated. Because as it turns out, “retinoid” is a catch-all term for a bunch of different types of compounds, all of which work in slightly different ways. And on top of that, the testing required to demonstrate efficacy isn’t exactly held to the highest of standards. But we do the best with what we have to get to the bottom of this retinoid puzzle. Tune in to learn everything you ever wanted to know about retinoids. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu Learn more about your ad choices. Visit megaphone.fm/adchoices