Dr. Laurie Santos: How to Achieve True Happiness Using Science-Based Protocols

In this episode, I discuss how different forms of exercise impact brain health and performance in both the short and long term. I explain how many of the positive effects of exercise on brain function occur through the action of specific neurochemicals that increase alertness. I also cover how to best time exercise and which specific types of exercise to include in your weekly routine to maximize benefits for your brain. Additionally, I explain how certain types of exercise trigger the release of a hormone from your bones called osteocalcin, as well as brain-derived neurotrophic factor. Together, these substances increase neuroplasticity and enhance learning. The positive effects of exercise on brain oxygenation, blood supply, and fuel utilization are also discussed. Listeners will learn how to design a weekly exercise program that optimizes physical fitness, brain health, longevity, and performance, along with the mechanistic logic behind those recommendations. Find show notes with articles, resources and more at hubermanlab.com. Pre-order Andrew's upcoming book, Protocols: https://go.hubermanlab.com/protocols Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Maui Nui: https://mauinui.com/huberman Timestamps 00:00:00 Exercise, Brain Health & Performance; Protocols Book 00:04:03 Sponsors: BetterHelp & Helix Sleep 00:06:55 Brain Health, Cardiovascular & Resistance Training 00:11:51 Exercise & Positive Impact on Brain Performance; Arousal 00:18:20 Learning & Arousal 00:23:18 Sponsors: AG1 & David 00:26:01 Exercise & Acute Learning 00:29:16 Tool: High-Intensity Training & Cognitive Flexibility; Over-Training 00:33:32 Long-Term Brain Health; Tool: Exercise “Snacks”, Cognitive Performance 00:36:57 Exercise, Brain & Body Energy, Adrenaline, Norepinephrine 00:44:08 Adrenal “Burnout”?; Exercise to Increase Energy, Adrenaline 00:48:20 Tool: Core, Compound Movements; Mind-Body Connection 00:53:58 Sponsor: Function 00:55:45 Bones, Osteocalcin, BDNF & Hippocampus; Tool: Jump Training 01:01:30 Exercise, Fuel, Multifactorial Pathways; BDNF & Activity 01:05:06 Lactate, Astrocytes & Brain Function; VEGF & Brain Health 01:11:17 Tools: Zone 2, High-Intensity Training, Time Under Tension Training 01:19:54 Sponsor: Maui Nui 01:21:37 Tools: Time Under Tension; Explosive Jumping, Eccentric Control Training 01:25:30 Injury & Exercise, Illness 01:28:09 Sleep; Injury, Sleep-Deprivation & Exercise 01:33:51 SuperAgers, Anterior Mid-Cingulate Cortex, Grit & Persistence 01:42:04 Tool: Embrace Challenges; Deliberate Cold Exposure, Rope Flow 01:47:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

In this Huberman Lab Essentials episode, I explain how to boost creativity and enhance learning by aligning with the body’s natural rhythms and strategically using protocols to optimize states of alertness or calm. I outline tools to improve focus and learning, including when to use specific techniques based on the time of day and how to adjust focus and tasks according to energy levels. I also discuss the two essential components of creativity and explain how to structure productive, creative work sessions. By combining biological tools — such as exercise, meals, hydration, and sleep — with subjective methods like music, I demonstrate how to tailor your approach to align with your unique biological rhythms and individual goals, fostering greater creativity and learning. Huberman Lab Essentials are short episodes, approximately 30 minutes, focused on key scientific and protocol takeaways from past Huberman Lab episodes. Essentials are released every Thursday, while full-length episodes continue to be released every Monday. Read the full show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Neuroplasticity 00:01:50 Types of Neuroplasticity  00:03:46 Autonomic Arousal, Sleep 00:05:06 Sponsor: AG1 00:06:34 Waking Up, Tools: Sunlight, Caffeine Delay, Hydration 00:09:39 Alertness, Morning & Work Bout 00:10:05 Dopamine & Learning; Tool: Music & Alertness 00:14:24 Sponsor: David 00:15:40 Tool: Exercise Early; Morning Work 00:16:58 Meals; Afternoon Dip & Work, Tools: Hydration, Non-Sleep Deep Rest (NSDR) 00:19:21 Creativity: Exploring vs. Implementation 00:21:44 Psychedelics, Sensory Blending; Tool: Timing Creative Work 00:23:50 Sponsor: LMNT 00:24:07 Tool: Evening Sunlight; Lights, Evening Meal & Carbohydrates 00:26:09 Natural Sleep/Wake Schedule; Tools: Anticipate Evening Alertness; NSDR 00:30:25 Work & Daily Schedule, Tool: 90-Minute Work Bouts 00:31:43 Optimize Biological Rhythms & Tools for Creativity & Learning  Disclaimer & Disclosures

In this episode, my guest is Dr. Jordan Peterson, Ph.D., psychologist, professor emeritus at the University of Toronto, best-selling author, and prominent online educator. We discuss the biology of human emotions and motivations, healthy versus destructive impulses, addictions, and generative drives. Topics include how brain states shape decision-making—for better or worse—and how religion and culture can guide us toward and through the best paths in life. We also explore the innate human drive to create "impact at a distance" and how it influences social interactions, educational pursuits, career choices, and relationships. Additional subjects include morality, social media, politics, the human appetite for drama, and the importance of embracing responsibility as a form of adventure to avoid wasting time. Listeners will gain practical knowledge from psychology, neuroscience, philosophy, and religion. Read the full show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Levels: https://levels.link/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Jordan Peterson 00:02:32 Sponsors: David & Levels 00:05:19 Brain, Impulses, Integration, Personalities 00:14:08 Personalities, Motivation 00:18:18 Context & Children; Religion, Motivation & Personality 00:24:08 Hypothalamus, Context, Maturation 00:29:46 Psychopathy, Kids & Aggressive Behavior & Socialization 00:33:37 Polytheistic & Monotheistic Religions; Rage, Sociopathy & Addiction 00:41:05 Sponsors: AG1 & ROKA 00:43:58 Belief in God, Addiction 00:50:34 Pornography, Dopamine, Processed Foods 00:56:20 Clean Diet, Satiety; Fundamental Pleasures, Food, Sexuality 01:04:44 Power, Target, Sin 01:06:46 Sponsor: Function 01:08:33 Abraham; Call to Adventure, Success, Respect, Community 01:21:30 Wisdom, Noah; Religion, Incentive Structure & Motivation 01:26:52 Dopamine & Target, Sin; Frontal Eye Fields 01:31:59 Meta-Target & Goals, Sermon on the Mount; Fears 01:40:36 Sponsor: LMNT 01:41:51 Ultimate vs. Local Victory, Pearl of Great Price 01:45:05 Time Scales & Rewards; Entropy, Dopamine & Goals 01:51:20 Pornography, Effortless Gratification; Revelation & Sexuality Demise 02:02:33 Adventure & Responsibility, Sacrifice; Tool: Ordering Room 02:12:02 Storytelling, Science, Career Advancement, Pursuing Truth 02:23:46 Abraham & Adventure; Purposeful Satisfaction, Podcast 02:28:13 Finding Your Calling, Tools: Calling & Conscience; Creating Order 02:35:06 Order vs. Chaos; Public Shootings, Narcissism 02:40:16 Long-Term Goals, Pursuit, Curiosity, Commitment 02:45:43 Finding Purpose, Tool: Fixing Messes; Conscience & Voice of Divine 02:54:26 Prayer, Aim, Revelation; Thought 03:00:34 Religion, Common Themes 03:10:55 Psychoanalytical Traditions; Play 03:19:23 Play; Humor, Discourse, Alternative Media 03:27:18 Democrats, Republicans; Fear & Growth 03:34:59 Tour, Peterson Academy, YouTube, Cancel Culture 03:48:30 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

In this Huberman Lab Essentials episode, I explain how making mistakes and perceived frustration drive learning and how movement enhances the brain’s adaptability.  I explain how making errors triggers the release of neurotransmitters, such as dopamine, which are essential for learning. I also discuss the differences between how neuroplasticity occurs in children and adults, focusing on the varying requirements and effort needed for learning. I discuss science-supported learning strategies for adults, including small practice bouts, leveraging frustration, regulating your autonomic state, and using movement to maximize focus and neuroplasticity.  Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the full show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Learning 00:01:29 Representational Plasticity, Performance Errors 00:03:16 Neuroplasticity, Neurotransmitters 00:05:03 Sponsor: AG1 00:06:11 Visual Adaptation, Children vs. Adults 00:10:23 Errors, Frustration & Neuroplasticity, Adult Learning 00:14:13 Adults, Incremental Shifts vs. High Contingency; Tool: Small Learning Bouts 00:18:43 Sponsor: David 00:20:00 Tool: Ultradian Cycles, Focus, Errors & Frustration 00:22:08 Dopamine, Errors & Subjective Beliefs; Peak Focus; Tool: Frustration 00:25:56 Sponsor: BetterHelp 00:27:02 Limbic Friction; Tool: Behaviors to Increase Alert or Calm 00:30:43 Balance, Errors & Neurotransmitters 00:33:28 Tool: Enhance Neuroplasticity; Movement Disclaimer & Disclosures

In this Huberman Lab Essentials episode, I explain how neuroplasticity allows the brain to continue to adapt and change throughout life, particularly through focused attention and active engagement in learning. I explain how neuroplasticity differs in children and adults, highlighting the key neurochemicals required for adult learning. I explain science-supported protocols to boost alertness and improve attention, including techniques like visual focus and goal accountability. I also discuss how sleep, along with practices such as non-sleep deep rest (NSDR) and naps, support the brain to enhance learning.  Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the full show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman More Huberman Lab Huberman Lab Premium: https://go.hubermanlab.com/premium Huberman Lab Merch: https://go.hubermanlab.com/merch Timestamps 00:00:00 Huberman Lab Essentials; Neuroplasticity 00:03:27 Sponsor: David 00:04:43 New Neurons; Sensory Information, Brain & Customized Map 00:07:40 Recognition, Awareness of Behaviors 00:09:58 Sponsor: AG1 00:11:06 Attention & Neuroplasticity 00:15:40 Epinephrine, Acetylcholine & Nervous System Change 00:18:20 Improve Alertness, Epinephrine, Tool: Accountability  00:20:39 Improve Attention, Acetylcholine, Nicotine 00:23:09 Sponsor: LMNT 00:24:26 Tool: Visual Focus & Mental Focus 00:29:54 Tool: Ultradian Cycles, Anchoring Attention 00:31:00 Sleep & Neuroplasticity; NSDR, Naps 00:33:34 Recap & Key Takeaways 00:36:38 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Recommendations, Sponsors Disclaimer & Disclosures